Cancer Pathogenesis Of Cancer - 1058 Words

There has been a spontaneous advancement in the understanding the pathogenesis of cancer over the last two decades. Even though there has been a significant success in the knowledge of tumor, there still a wide gap in the treatment of tumors. There is a little treatment information available on cancer making it difficult to control it. Chemotherapy remains the only effective treatment method used. This study aims at examining the possible roles of the p53 gene in leukemia and how that data can be utilized for diagnosis and treatment of cancer. Due to its potent tumor suppressive activity, a molecular understanding of p53 action will create significant experiences into specific procedures that limit tumor growth and may identify key†¦show more content†¦There are essentially two pathways that transduce signs to start apoptosis in leukemia. The primary route is the extrinsic pathway. It includes the trimerization of death factors like CD95/Fas/APO-1 or TNF receptor one which initiates caspase 8, which initiates the apoptotic machinery. The second pathway is the intrinsic pathway. This pathway involves the p53 gene and is subsequently of more concern. The p53 gene initiates the arrival of cytochrome C from the mitochondrial intermembrane space into the cytosol. The cytochrome C in the presence of ATP reasons the oligomerization and activation of Apaf-1 and caspase 9 as per Schuler, (2000). Therefore, then prompt caspase three and other effector caspases that cause apoptosis. By utilizing this data, experiments have been carried out that try to induce apoptosis in cancer cells by activation of the p53 gene. One particular examination was done on the human osteosarcoma cell line Saos-2, which is deficient in p53. According to Schuler (2000), an introduction of the p53 gene led to apoptosis through an intrinsic pathway. Subsequently subjecting p53 to gene treatment might be of enormous importance in the battle against leukemia. According to Liu (1994), it has additionally been discovered that p53 mutant tumors are more unstable genetically and this state of instability may enable the tumors to become more rapidly resistant to drug treatments. Since p53Show MoreRelatedPathogenesis of Cervical Cancer2028 Words   |  9 PagesCELL BIOLOGY ESSAY -- PATHOGENESIS OF CERVICAL CANCER Introduction According to the Centre for Health Protection of the Department of Health (2011), cervical cancer becomes the tenth commonest cancer in Hong Kong in 2008. Cervical cancer usually arises from sexual activity and human papillomavirus (HPV) (Bellentir, 2002). In this essay, Human papillomavirus would be further discussed. 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